"Tuberculosis Immunization" Dr Eugene Lindsay Opie Hand Written Note

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"Tuberculosis Immunization" Dr Eugene Lindsay Opie Hand Written Note:
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Up for sale "Tuberculosis Immunization" Dr. Eugene Lindsay Opie Hand Written Note.

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Eugene Lindsay Opie (5

July 1873 – 12 March 1971) was conducted research on the causes,

transmission, and diagnosis of tuberculosis and on immunization against the disease. He

served as professor of pathology at several U.S. medical schools and as Dean School of Medicine (St. Louis, Missouri). Opie was born in Staunton, Virginia, on July 5, 1873. His

father, Thomas, was an obstetrician-gynecologist, and one of the founders and deans of the University of Maryland College of

Medicine in Baltimore.[1] Eugene attended Johns Hopkins

University, both as an undergraduate and a medical student. He received an A.B. degree in 1893,

and was in the first graduating class of the Johns Hopkins Medical School,

earning the M.D. degree in 1897.

Under

the tutelage of the pathologist William H. Welch, Opie developed a special affinity for tissue

pathology. As a medical student, he observed consistent morphological

alterations in the pancreatic islets of Langerhans in

patients with diabetes mellitus –

an observational epiphany that shed light on the pathogenesis of that disease.[3] Opie stayed on at Johns Hopkins

after completing medical school, to receive additional training in pathology

from Welch. He continued his work on pancreatic diseases, establishing the

relationship between obstruction of the ampulla of Vater (e.g., by gallstones) and the subsequent development of acute pancreatitis. In

1904, Opie moved to New York City to work

at the Rockefeller Institute,

with a focus on the enzymatic constituents of leukocytes and their role in inflammatory conditions. He

concurrently served as a "visiting" pathologist and was named an editor of the Journal of

Experimental Medicine and the Proceedings of the Society for

Experimental Biology. In

1910, Opie was appointed Chair of Pathology at Washington

University School of Medicine (WUSM) in St. Louis. He served as Dean of the school from 1912 to 1915, presiding over a

significant expansion of its physical facilities, scientific mission, and

curriculum. When

the United States entered World War I, Opie took a leave of absence from WUSM to enter

the U.S. Army. He served in France as a colonel (O6) in the Medical Corps,

with special work on infectious diseases and

their prevention among allied soldiers. Significant new data were and "trench fever" (bartonellosis) during that time. Upon returning to

civilian life, Opie continued his duties at WUSM until 1923. Opie narrowed his

general interest in infectious disease to focus on tuberculosis, an

international scourge in the early part of the 20th century. In 1923 he became

the Director of the Phipps Institute for the Study and Treatment of

Tuberculosis at the University of Pennsylvania in Philadelphia. A concomitant appointment as Professor of

Pathology was also given to him. Through Opie's work over the next decade, much

was learned about the modes of tuberculous infection in children and adults, as

well as aspects of immunity, hypersensitivity, and cellular defenses regarding that

disease. Opie moved to Cornell University Medical

Center in New York in 1932 to continue his research. There, as chair of the

Pathology department, he recruited several young pathologists—including Robert

A. Moore, D. Murray Angevine, Jules Freund, and others – who would all go on to

distinguish themselves as renowned investigators in their own rights. Like

Opie, Moore also served as chair of pathology and dean of the medical school at

Washington University in the 1940s and 1950s.